Previous data in normal subjects demonstrate an average radiation exposure of 0.9 mSv/20 mCi for Rb-82. 16 This translates to 2 to 6 mSv per study, depending on whether a 2-dimensional (2D) or 3D system is used. 8 Case et al 8 estimated achievable rubidium radiation exposure levels of 2 mSv for 3D systems and 4 mSv for 2D systems.Web

These drawbacks make rubidium a better choice as a potassium-analog. Rubidium-82 is suitable for positron emission tomography, because Rubidium-82 is a positron emitter rendering higher quality images than conventional gamma camera imaging. Moreover Rubidium-82 is a radionuclide with an ultra-short half-life (t 1/2 =75s). This ultra-short …Web

82 Rb has the same biological properties as potassium (K +) and is extracted by the myocardium through the Na-K-ATPase pump. 82 Rb is taken up in viable myocardium, whilst it is rapidly cleared from fibrotic tissue. The extraction of 82 Rb during the first pass is high (65%) but decreases in a non-linear way with increasing blood flow …Web

Le générateur est destiné à la production d'une préparation radio-pharmaceutique avec du chlorure de 82Rb, qui est rincé à partir du sorbant puis introduit dans le corps du patient afin de diagnostiquer différentes maladies par tomographie à émission de positon; les isotopes de strontium-82 et 85 doivent rester sur le sorbant et ne ...Web

Rubidium-82 (82 Rb) is a PET myocardial perfusion tracer that is produced with a strontium-82 (82 Sr)/ 82 Rb generator and is widely used for the diagnosis of CAD in centers without immediate access to an on-site cyclotron [3], [4]. Therefore, 82 Rb perfusion studies could be applied in larger populations [5], [6].Web

Infusion System User's Guide for the set up and intravenous infusion of rubidium Rb 82 chloride injection dose(s). 2.2 Rubidium Rb 82 Chloride Injection Dosage . The recommended adult single dose of rubidium Rb 82 chloride injection is 1480 MBq (40 mCi) with a range of . 1110-2220 MBq (30-60 mCi). Do not exceed a single dose of 2220 MBq …Web

Rubidium-82 has a long story, starting in 1954. After preclinical studies in dogs showing that myocardial uptake of this radionuclide was directly proportional to myocardial blood flow (MBF ...Web

WO2006135374A2: : RUBIDIUM-82 GENERATOR BASED ON SODIUM NONATITANATE SUPPORT, AND IMPROVED SEPARATION METHODS FOR THE RECOVERY OF STRONTIUM-82 FROM IRRADIATED TARGETS: Other References: "Experience with a 82Sr/82Rb Generator for Clinical Use," Kensett, M., et al., Appl. …Web

Générateur de strontium-82/rubidium-82, procédé de production de rubidium-82 comportant un agent de diagnostic, cet agent de diagnostic et son utilisation médicaleWeb

For rubidium-82 PET imaging, they considered an estimated effective dose of 15 mSv for a rest/stress test using an injected activity of 1480–2250 MBq and a 2D PET camera. Cancer risk projection models were based on the National Research Council Biological Effects of Ionizing Radiation VII report assuming a linear relationship with …Web

rubidium generator strontium buffer column Prior art date Application number PCT/EP2009/060584 Other languages English (en) French (fr) Inventor Roland Anthonius Maria Johannes Claessens Original Assignee Stichting Jeroen Bosch Ziekenhuis Priority date (The priority date is an assumption and is not a legal conclusion.Web

US20050058839A1 US10/894,870 US89487004A US2005058839A1 US 20050058839 A1 US20050058839 A1 US 20050058839A1 US 89487004 A US89487004 A US 89487004A US 2005058839 A1 US2005058839 AWeb

82 Rb is produced from an 82 Sr– 82 Rb generator, which has a clinical life of 4–6 weeks. The 82 Rb is administered by remote intravenous infusion and the generator can be eluted with >90% yield every 10 min. 82 Rb is a potassium analogue and it crosses the capillary membrane rapidly, partly using the sodium–potassium exchange transporter.Web

Rubidium-82 Dosage Rubidium chloride Rb 82 injection obtained from Cardiogen-82 (Rubidium Rb 82 Generator) is intended only for intravenous administration utilizing an appropriate infu-sion system that is labeled for use with the generator. The usual adult (70 kg) dose (single injection) is 1480 MBq (40 Rubidium Rb 82 Generator ®Web

Rubidium-82 | Rb | CID 5464265 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety ...Web

Results: Eighteen original studies were selected and included in the final analysis out of 803 articles identified at the initial research. Overall, the mean value of …Web

Global MFR values of this patient were 1.72 using the D690 (intermediate risk) and 1.40 using the Vereos (high risk). It is well known that perfusion defects can be introduced due to misregistration of attenuation CT and PET data. 23, 24, 25 For each scan, we verified the co-registration between CT and PET data.Web

Ruby-Fill (rubidium Rb 82 generator) is a closed system used to produce rubidium Rb 82 chloride injection for intravenous use. Rubidium Rb 82 chloride injection is a radioactive diagnostic agent indicated for Positron Emission Tomography (PET) imaging of the myocardium under rest or pharmacologic stress conditions to evaluate regional …Web

1 INDICATIONS AND USAGE. RUBY-FILL is a closed system used to produce rubidium Rb 82 chloride injection for intravenous administration. Rubidium Rb 82 chloride injection is indicated for Positron Emission Tomography (PET) imaging of the myocardium under rest or pharmacologic stress conditions to evaluate regional …Web

Cardiac PET/CT. Rubidium-82. N-13 ammonia. O-15 water. F-18 flurpiridaz. Myocardial metabolism. Download chapter PDF. Positron emission tomography (PET) is a non-invasive imaging technique that employs positron-emitting radionuclides labelled to biological molecules. Unlike other imaging techniques, such as computer tomography …Web

2.1 Radiation Safety - Drug Handling. Rubidium Rb 82 is a radioactive drug and should be handled with appropriate safety measures to minimize radiation exposure during administration [see Warnings and …Web

Atomic number (number of protons in the nucleus): 37. Atomic symbol (on the periodic table of elements): Rb. Atomic weight (average mass of the atom): 85.4678. Density: 0.886 ounces per cubic inch ...Web

Rubidium-82 has a long story, starting in 1954. After preclinical studies in dogs showing that myocardial uptake of this radionuclide was directly proportional to myocardial blood flow (MBF), clinical studies were …Web

in the rubidium Rb 82 chloride injection exceed limits. (5.1) Perform generator eluate tests: 1) Record each eluate volume, including waste and test volumes. (2.4) 2) Determine Rb …Web

decays to rubidium-82 (82Rb), the daughter nuclide. Cardiogen-82 is a radionuclide generator of rubidium-82 (82Rb) containing strontium-82 (82Sr) adsorbed on stannic oxide in a chromatography column. It provides a means of obtaining, via elution, a sterile, non-pyrogenic injectable solution of rubidium-82 (82Rb) chloride.Web

Rubidium-82 has a long story, starting in 1954. After preclinical studies in dogs showing that myocardial uptake of this radionuclide was directly proportional to …Web

Mechanism of action. Rb-82 is analogous to potassium ion (K+) in its biochemical behavior and is rapidly extracted by the myocardium proportional to the blood flow. Rb+ participates in the sodium-potassium (Na+/K+) ion exchange pumps that are present in cell membranes. The intracellular uptake of Rb-82 requires maintenance of …Web

On the other hand, for 82-Rubidium-PET, the mean value of sensitivity and specificity for diagnosis of CAD was 81% and 81%, respectively. The accuracy of diagnostics of these imaging modalities was dependent on the radiotracers and stress agent used in these studies, with 99mTc-MIBI achieving the highest diagnostic value.Web

WO2006135374A2 (en) * : : Lynntech, Inc. Rubidium-82 generator based on sodium nonatitanate support, and improved separation methods for the recovery of strontium-82 from irradiated targets RU2467692C1 (ru) * : : ...Web

WO2006135374A2: : RUBIDIUM-82 GENERATOR BASED ON SODIUM NONATITANATE SUPPORT, AND IMPROVED SEPARATION METHODS FOR THE …Web

Methods for setting up, maintaining and operating a radiopharmaceutical infusion system, that includes a radioisotope generator, are facilitated by a computer of the system. The computer may include pWeb

Rubidium Rb 82 injection is used in adults to help diagnose heart disease. It is used in a procedure called a positron emission tomography (PET) scan to help your …Web

Strontium-82/rubidium-82 generator, method for producing a rubidium-82 comprising diagnostic agent, said diagnostic agent and its use in medicineWeb

Par ailleurs, ces compositions n'ont qu'une très faible affinité pour le rubidium, ce qui en fait un matériau idéal comme générateur de 82Rb . Les matériaux de sodium nonatitanate de ce type améliorent la récupération de 82Sr tout en constituant un système de générateur de 82Rb plus sur et plus efficace. ...Web