Arsenic-contaminated beer resulted in 6,000 poisonings and approximately 71 deaths in Northern England in 1900. Sulfuric acid contaminated with arsenic, which was used to …Web

Chronic arsenic toxicity is associated with various clinical manifestations known as arsenicosis. Pigmentation and keratosis are the specific skin lesion characteristics of chronic arsenic toxicity. ... [14], although less commonly seen. Pigmentation is not histopathologically related to arsenical hyperkeratosis, nor is it a direct precursor of ...Web

Acute toxicity following ingestion, inhalation, or absorption of inorganic arsenic produces a burning sensation in the mouth and throat. This is followed, usually somewhat later, by severe gastrointestinal distress with copious and severe diarrhea and vomiting. Vertigo, delirium, coma, and often convulsions are seen as the toxicity is manifest.Web

Arsenic has also been used as a homicidal agent. In cases with absent forthcoming relevant clinical history suggestive of arsenic toxicity, diagnosing cases of an acute arsenic toxicity is extremely challenging because of highly varied and multifaceted clinical presentation. The gastrointestinal (GI) manifestations are usually characteristic in ...Web

Arsenic poisoning occurs when you ingest or consume high levels of arsenic. It shares features of other heavy metal poisonings, including mercury and lead. You can experience arsenic poisoning quickly, but long-term exposure to the element is more common. This may be through contaminated groundwater, …

Figure 1. (A) Rain drop pigmentation seen over posterior aspect of trunk. (B) Mees' lines seen in fingernails. In India ∼80% of the population uses herbal medicine products. 1 Studies have shown that these preparations contain significant amount of heavy metals like arsenic, lead, mercury and cadmium, well above the safety levels. 2 The ...Web

In general poisoning with inorganic arsenic is commonly seen in cattle, while organic arsenic poisoning is more commonly seen in swine. Arsenic inhibits the activity of sulfhydryl-containing enzymes, which are essential to cellular metabolism. Toxic effects of arsenic are due to blockage of carbohydrate and fat metabolism and cellular respiration.Web

Initial symptoms of acute arsenic xide poisoning (occurring within 30 minutes to several hours) include burning of the lips, pharyngeal constriction, severe abdominal pain, and …Web

Arsenic toxicity has been reported in many countries including China, Pakistan, Bangladesh, ... In liver tissue of C. batrachus and C. punctatus hepatic pathologies were seen in the form of congestion, cloudy hepatocyte swelling, karyolysis, vacuolar degeneration and nuclear hypertrophy dilatation of sinusoids .Web

Other findings in acute arsenic poisoning may include fever and facial edema. Several months after poisoning, Mees lines (or Aldrich-Mees lines) may be seen, reflecting transient disruption of nail plate growth during acute poisoning. In episodes of multiple acute exposures, several Mees lines may occur within a single nail. In someWeb

Lower-dose chronic arsenic exposure can result in subacute toxicity that can include skin changes and skin cancer, peripheral sensorimotor neuropathy, diabetes …Web

Laboratory Studies. No specific test is available for arsine exposure; however, arsine exposure may be confirmed by detection of elevated arsenic levels in urine (> 50 mcg/L for a spot test or > 50 mcg for a 24-hour urine test) and signs of hemolysis (eg, hemoglobinuria, anemia, or low haptoglobin). In addition, arsine may be detected in ...Web

Trestrail has since compiled a total of 1026 documented "poisoning crimes" for which the accused person was convicted, including an unstated number of historical cases but also recent killings (20th and …Web

B. Chronic Poisoning: Chronic arsenic poisoning is much more insidious in nature, often involving multiple hospital admissions before the correct diagnosis is made. Arsenical dermatosis was rarely picked up from the variety of so many dermato sis. The source of arsenic exposure is discovered in fewer than 50% of cases. The mostWeb

However, it remains to be seen if a similar mechanism is responsible for arsenic-induced pulmonary toxicity and fibrosis in humans. Based on a rural population study in Bangladesh, it was found that individuals consuming arsenic-contaminated drinking water are at a higher risk of developing lung cancer (Mostafa et al., 2008 ).Web

Even considering that most acute arsenic poisoning occurrences are due to accidental ingestion of arsenic-containing pesticides and less ... Files, D.; Corey, G.R. Arsenic poisoning seen at Duke …Web

Key facts Arsenic is naturally present at high levels in the groundwater of several countries. Arsenic is highly toxic in its inorganic form. Contaminated water used …Web

Arsenic has been found in hair as early as thirty hours and as late as nine years after ingestion of the poison. 21 Normal values have ranged from 0.025 to 0.088 mg. per 100 gm. of hair 22 ...Web

Evaluation for arsenic toxicity requires a detailed history, including environmental and occupational exposure history,... For recent and chronic exposure, the 24-hour urine …Web

Arsenic compounds are well absorbed within 24 hours and redistributed to the liver, lungs, intestinal wall, and spleen, where they bind to the sulfhydryl groups of tissue proteins. Arsenic also replaces phosphorus in the bone where it may remain for years. Hence, chronic poisoning can be detected years after exposure has stopped.Web

TOXICITY. The medicinal use of arsenic, although practiced for hundreds of years, apparently reached a peak in the middle to late 1800's and was a major mainstay in the limited medical armamentarium of the time. 815 …Web

water), the first changes are usually seen in the skin: pigmentation changes and then skin lesions and hard patches on the palms of the hands and soles of the feet, which ... • Monitor high-risk populations for early signs of arsenic poisoning, usually skin problems. It should be noted that total urinary arsenic does not differentiate betweenWeb

Definition / general. Arsenic intoxication is associated with acute and chronic adverse health effects. Arsenic is pervasive in water, soil, air; has natural and anthropogenic sources. Its metabolism involves reduction to a trivalent state and oxidative methylation to a pentavalent state; the trivalent arsenicals, including those methylated ...Web

Periacinar fibrosis and a poorly differentiated cholangiocarcinoma were seen in liver. In pancreas, reduced cell density of islands of Langerhans was noticeable. ... It can be concluded that long-term consumption of arsenic contamined water and forage may be associated with chronic arsenic poisoning in domestic animals and human beings, with ...Web

Arsenic poisoning is not a local problem, it is a global public health concern. ... Although meat and milk contain high levels of arsenic, arsenic toxicity is not commonly seen in domestic animals because arsenic is rapidly excreted in the urine (El Bahri and Romdane, 1991, Faires, 2004).Web

lI stitute Where is arsenic found in the U.S.? This map shows estimates of how many private domestic well users in each county may be drinking water with high levels of arsenic. …Web

The effects of arsenic poisoning differ depending upon whether the exposure is acute – a large dose in a short period of time – or chronic – lower doses over an extended period of time. ... These symptoms are also seen in people who live in regions where drinking water contains between 100 and 1,500 parts per billion of arsenic.Web

Arsenic was a convenient secret weapon for poisoners. Scientific innovation led to improvements in tests for arsenic in the 1830s and 1840s. In 1839, the first of the Rural Constabularies Acts was passed, which …Web

Summary. Arsenic is a natural element found in soil and minerals. Arsenic compounds are used to preserve wood, as pesticides, and in some industries. Arsenic can get into air, water, and the ground …Web

Arsenic toxicity from ingested water and food is a worldwide phenomenon capable of causing significant morbidity. Background. Arsenic exists naturally in the environment in various forms; some are toxic, some benign. ... Arsenic cannot be tasted, seen or smelled and can vary in concentration between wells even in a compact area, ...Web

Arsenic is a metalloid ubiquitous in the environment found in different forms (inorganic and organic) and oxidation states (−3, 0, +3, +5). ... Biomarkers of inorganic arsenic exposure are necessary to understand the mechanism of toxicity, and to assess the health impacts. Blood, urine, hair, and nails are the most common biological ...Web