Germanium is a key trace element in living organisms. A deficiency of it causes several diseases, including oncogenic ones [ 1 ]. The biological activity of Ge compounds was discovered long ago, e.g., the antitumor activity of its inorganic compounds was observed already in 1928 [ 2 ]. However, this area began to develop vigorously only …Web

A battery of OECD- and GLP-compliant toxicological studies was performed to assess the safety of a highly purified germanium sesquioxide, an organic form of the naturally occurring, nonessential trace element germanium. Germanium dioxide and germanium lactate citrate (inorganic germaniums) have been shown to induce renal toxicity, whereas …Web

For example, for the best-known organic germanium sesquioxide Ge-132 oral toxicity for mice is LD50 > 6300 mg/kg, oral for rats is >10000 mg/kg and intravenous toxicity for rats is >1000 mg/kg [58].Web

The results showed that compound 5 may be developed to be a suitable cancer therapeutic agent. View full-text. Article. ... Organic germanium compounds, especially Ge-132, more corrctly denoted as ...Web

The present invention is a cordyceps militaris mycelium containing a high concentration of organic germanium by liquid culture and pupa culture of Cordyceps sinensis and The present invention relates to a method for producing a fruiting body. Cicada cordyceps mycelia were prepared by liquid culture, and inorganic germanium (GeO2) was added to …Web

The primary sources of worldwide germanium production are Zn-refinery residue and coal fly ash, with recycling of industrial scraps being the secondary source [12].Globally, the main producer of germanium is China, accounting for 80% of world production during 2012–2016 [7].Other producers are Russia, Finland, US, Japan, and …Web

Germanium is an essential microelement, and its deficiency can result in numerous diseases, particularly oncogenic conditions. Consequently, water-soluble germanium compounds, including inorganic and coordination compounds, have attracted significant attention due to their biological activity. The review analyzes the primary …Web

Nowadays, germanium is still a comparatively rare element, however, one with great technological importance: its fields of application range from semi-conductor industries, and optical and telecommunication industries (in the form of the pure element and its compounds with sulphide and other chalcogenides) to applications in the biomedical …Web

Organic germanium is the most widely used form of germanium. Compared to the common metal (mercury, cadmium, lead, etc.), organic germanium is much less toxic to humans than others. Since its discovery in 1886, organic germanium and relative compounds have caused many medically related problems across the globe. In most …Web

Ge-132 is a water-soluble organic germanium compound whose safety has been established, and is currently used in the food and cosmetic industries. In future studies, it is hoped that methods can be developed to reduce the amount of morphine or ADA inhibitor administered to patients via co-injection with Ge-132.Web

ATP Blog02 - Organic Germanium,"Miracle Molecule" By- Dr. Kazuhiro Asai. Medical Benefits highlighted by ATPYou may want to print the various FULVIC - Humic Acid Report and other educational documents that we have and give it them to your doctor. ... To extract germanium from coal, I developed a process whereby the organic …Web

The crystal structural of the compound was confirmed, and Ge-132 was developed for 286 medical use as an anti-cancer drug to mediate immune modulation. However, Ge-132 could 287Web

Therefore, organic germanium is a kind of "internal Chizhevsky chandelier" [10, 11]. At the same time, organic germanium compounds are nontoxic, they have no side reactions and function in the body for a long time, and hence can be regarded as extremely prom-ising for use in medicine [5, 6]. Dolaychuk et al. [13] reported the results of ...Web

Germanium is naturally present in water and food, as it exists in soil, rocks, animals, and plants in organic and inorganic forms (Kang et al. 2001).Moreover, it is used in industry as a semiconductor and in the manufacture of phase-change optical magnetic discs, such as DVD-RAM and DVD-RW (Lin et al. 2006).The lack of recycling processes for …Web

Germanium is an element with an atomic number of 32, an atomic weight of 72.63, and a valence of +2 or +4 (Lide 1998 ). It belongs to a chemical group IVA in the periodic table that includes C, Si, Ge, Sn, and Pb. Its chemical properties are …Web

Compared to the common metal (mercury, cadmium, lead, etc.), organic germanium is much less toxic to humans than others. Since its discovery in 1886, organic germanium and relative compounds have ...Web

It becomes evident that, although very sophisticated technological uses of germanium exist, a better understanding of its biogeochemical importance, cycling and reactivity must still be developed.Web

Organic germanium is the most widely used form of germanium. Compared to the common metal (mercury, cadmium, lead, etc.), organic germanium is much less toxic to humans than others.Web

Poly-trans-[(2-carboxyethyl) germasesquioxane] (Ge-132) is the most common organic germanium compound. It was first synthesized by Oikawa et al., and …Web

Our findings suggest that organic germanium compound have potential to be developed as an antimicrobial agent against some bacterial infections. Discover the world's research 25+ million membersWeb

Germanium's existence was predicted before anyone isolated it. This was a triumph for Dmitri Mendeleev in his construction of the periodic table. By 1869, Mendeleev had assembled a crude table of the known elements, arranging them according to their chemical properties and atomic weights. But his table had a number of prominent gaps.Web

Bio-Germanium was developed in the late 1980s in the search for safer and more natural organic germanium. This new type …Web

1. Introduction. Germanium is a constituent of many medicine plants such as ginseng root, and it is considered to play an important role in the pharmacological effects of the plants [].It is reported that many organogermanium compounds can inhibit tumor and metastatic growth and modify immune response by inducing interferon-γ (IFN-γ), …Web

Some organic germanium compounds such as spirogermanium and Ge-132 have been used in medicine or as food additives. Although its physiological activity still remains to be explored, some germanium-containing organics are edible, which clearly is a advantage over Sn. ... Therefore, we have developed a series of germanium-containing …Web

Toxicological studies document Germanium's rapid absorption and elimination from the body, and its safety. Clinical trials and use in private practices for more than a decade …Web

Organic germanium is the most widely used form of germanium. Compared to the common metal (mercury, cadmium, lead, etc.), organic germanium is much less …Web

To extract germanium from coal, I developed a process whereby the organic germanium in coal is removed at high temperature in a carbonization furnace. It is then liquefied by adjusting the pH and burned to eliminate miscellaneous organics. ... Organic germanium may be regarded as an excellent agent for treating this disease …Web

Introduction At present, germanium is widely recognized as a vital trace element, which is particularly essential for the normal functioning of the immune system and plays a significant role in cancer …Web

Bio-Germanium was developed in the late 1980s in the search for safer and more natural organic germanium. This new type of organic germanium is formulated by a natural …Web

Germanium (Ge) is the element with atomic number 32. Being a member of the group 14 of the periodic table, it stands in many of its physical and chemical properties between the elements silicon and tin. While the element has important applications in the electronics, semiconductor, and optics industries, the organic compounds of …Web

Moreover, due to their high stability and low toxicity, they can be considered very useful reagents in the synthesis of complex organic molecules 4,12. The germanium analogues of siloxanes with Ge ...Web

To extract germanium from coal, I developed a process whereby the organic germanium in coal is removed at high temperature in a carbonization furnace. It is then liquefied by adjusting the pH and burned to eliminate miscellaneous organics. ... Organic germanium may be regarded as an excellent agent for treating this disease because of its ...Web