10. Cortez gold mine, USA. 1. South Deep gold mine – 32.8 million ounces (Moz) South Deep gold mine is the largest gold mine in the world, by reserves. Located 45km south-west of Johannesburg in the Witwatersrand Basin, South Africa, South Deep is also the seventh deepest mine in the world, with a mine depth up to 2,998m below the …Web