Patients receiving low intensity induction continued a low intensity approach until transplant unless additional "salvage" therapy was required for management of refractory disease prior to entering CR1. These patients remained in the low intensity cohort for analysis. All patients received central nervous system (CNS) prophylaxis with ...Web

Low-intensity HMA therapy with decitabine and azacitidine-based regimens is now the most common form of treatment among older ... Induction mortality from DIC is low (about 5%). Resistant disease is extremely rare, except in molecular variant-APL (translocations between chromosome 11 and 17 ...Web

Patients receiving low intensity induction regimens were significantly older. Discussion. Our study may suggest that acceptable long-term outcomes can be achieved for adults with Ph+ ALL consolidated with alloHCT in CR1 regardless of the intensity of the initial induction regimen. The 2-year OS of 62% and 63% in the low and high intensity ...Web

The paradigm of the low-intensity approach, low-dose cytarabine, has been used for decades in patients deemed unsuitable for intensive induction. In a large …Web

In this retrospective study, we compared the CR rate, minimal residual disease (MRD) negative rate, overall survival (OS) and event-free survival (EFS) rates between low …Web

Effect of induction intensity and ASCT in CR1 on patients stratified by karyotypic complexity. In those patients with a CK, treatment with an intensive cytarabine containing induction regimen vs low-intensity regimen had no statistically significant effect on median OS (4.5 vs 3.8 years, p=0.77) nor median PFS (2.3 vs 1.5 years, p=0.45).Web

Introduction. Acute myeloid leukemia (AML) is the second most common leukemia in adults. In 2019, an estimated 21,450 new cases and 10,920 deaths were reported in the United States. 1 Older adults account for most cases, with a median age of 68 years at diagnosis. Incidence rates of AML increase with age from 1.3 per 100,000 in …Web

Scientific Reports - Low-intensity pulsed ultrasound therapy promotes recovery from stroke by enhancing angio-neurogenesis in mice in vivo. ... Induction of transient focal cerebral ischemia.Web

There are two key laws that describe electromagnetic induction: Faraday's law, due to 19ᵗʰ century physicist Michael Faraday. This relates the rate of change of magnetic flux through a loop to the magnitude of the electro-motive force E. ‍. …Web

Recently, with effective non-intensive options, such as venetoclax (Ven) combinations, or IDH inhibitors, we offered low intensity re-induction to select pts with persistent disease after initial intensive therapy as a potential means of reducing morbidity, and potentially improving chance for response. This study describes the characteristics ...Web

Low Intensity Alternative Induction Therapy for Acute Myeloid Leukemia (AML). Real World Experience from Tawam Hospital, United Arab Emirates ... intermediate risk n= 9 poor risk n=3, metaphase failure n=4. Alternative induction reasons included age (n=9), co-morbidities (n=10) (Obesity, respiratory failure, cardiomyopathy, pul- monary …Web

In older and unfit patients unable or unwilling to undergo a transplant, use of TKIs in addition to low-intensity chemotherapy does produce high response rates with minimal or no induction mortality. 19,40,41 However, it does not appear that such a strategy can produce long-term RFS, and perhaps future regimens incorporating blinatumomab or ...Web

There was no difference between the low and high induction intensity cohorts in the proportion of patients requiring a salvage regimen to achieve CR1 (14% vs. 16%, p=0.77). Following induction, molecular MRDneg status was similar in the low and high intensity cohorts (54% and 52% respectively, p=0.99).Web

Background and Objectives: This study aimed to evaluate whether the addition of hypomethylating agents (HMA) to low-intensity chemotherapy can enhance the clinical efficacy of induction treatment for elderly acute myeloid leukemia (AML) patients who are unsuitable for standard induction therapy.Materials and Methods: This study …Web

When evaluating low-intensity therapies for acute myeloid leukemia (AML), emphasis is usually placed on inpatient versus outpatient management of patients. In …Web

57% of the 932 patients received high intensity treatment, 21% intermediate intensity, and 23% low intensity. Covariates significantly associated with receipt of high vs. intermediate/low intensity on multivariable analysis were younger age, (surprisingly) PS 3-4 (OR 1.4, 95% CI 1.1, 1.8), lower TRM score, and > 20% blasts. The model's AUC was ...Web

Both 30 s and 30 min of low-intensity ultrasound was used to stimulate brain tissue at the induction window . The 2-dimensional distribution of the ultrasound field measured by a calibrated needle-type hydrophone (HNR500, Onda) is plotted in Fig. 3B. As the ultrasound transducer and the coupling cone are placed obliquely, the cross section …Web

Low-intensity regimens versus standard-intensity induction strategies in acute myeloid leukemia. Norbert Vey. Therapeutic Advances in Hematology 2020 10.1177/2040620720913010 ... Low-intensity therapies have been particularly impacted by this since many new drugs can be safely combined with HMAs, allowing for the …Web

Use the equation Φ = B A cos θ to calculate the magnetic flux. Φ = B A cos θ = B π ( d 2 ) 2, 20.30. where d is the diameter of the solenoid and we have used cos 0° = 1 . Because the area of the solenoid does not vary, the change in the magnetic of the flux through the solenoid is. Δ Φ = Δ B π ( d 2 ) 2 . 20.31.Web

The initial data for the most widely utilized intensive induction chemotherapy regimen for acute myeloid leukemia (AML), a combination of cytarabine and an anthracycline ("7+3"), were published in 1973. 1 In the subsequent four decades the question of increasing or decreasing the intensity of induction had been asked multiple times.Web

Overall, 33% percent of the total cohort achieved a complete remission (CR) with initial treatment, 23% with low-intensity induction and 53% with standard …Web

Low-intensity regimens for AML. Standard low-intensity regimens utilize LDAC or HMAs. LDAC corresponds to various dose schedules with doses inferior to 50 mg/day given as subcutaneous injections. No standard schedule has yet been …Web

Low intensity pulsed ultrasound (LIPUS) has been demonstrated to possess therapeutic effects on neuronal diseases and stroke via brain-derived neurotrophic factor (BDNF) induction. In this study, we hypothesized that LIPUS treatment possessed therapeutic benefits for the improvement of stroke recurrence.Web

The prognosis of elderly patients with acute myeloid leukemia (AML) is poor, and the recommendation of standard-dose or low-intensity induction regimen for these patients remains controversial. We retrospectively analyzed treatment outcome and prognostic factors of elderly AML patients who had received either standard-dose or low-intensity ...Web

The induction chemotherapy regimen used in this study was a lower intensity version of conventional hyper-CVAD (hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone alternating with methotrexate and high-dose cytarabine) and referred to as mini-hyper-CVD, which reduces cyclophosphamide and …Web

It is hypothesized that low-intensity CC integrated into induction and/or consolidation (as being pursued by EWALL-INO and GMALL INITIAL-1 studies) may …Web

The main benefit of using a low-intensity acoustic field is the possibility of avoiding problems such as excessive cavitation and heating of adjacent normal tissues. ... The visual analysis demonstrated that the most effective intensity in terms of apoptosis induction was 0.05 W/cm 2 (Figure 4F). Open in a separate window. Figure 4. …Web

Modern low-intensity therapies have emerged with the development of HMAs. 31 Although associated with substantial hematologic toxicity, the limited nonhematologic toxicity of these drugs made them appropriate for the treatment of frail patients. In the AML001 study, 488 patients aged 65 years and above with newly …Web

Transcranial low-intensity pulsed ultrasound (LIPUS) therapy, ... For each LIPUS administration, the animals were anesthetized with isoflurane in an anesthesia system with an induction box (standard anesthetic/O 2, pre-established dosages); then, with the aid of Carbopol conductive gel, the ultrasound waves were induced …Web

In conclusion, dasatinib combined with low-intensity chemotherapy was well-tolerated and gave long-term survival in 36% of elderly patients with Ph(+) ALL. Monitoring of BCR-ABL1(T315I) from diagnosis identified patients with at high risk of early relapse and may help to personalize therapy.Web

In this study, we (1) report the outcomes of children with AML who received low-intensity induction chemotherapy, and (2) evaluate the quality of remission by using next-generation sequencing. From July 2012 to May 2016, 90 Chinese children with AML who had white blood cell counts less than 50.0×10 9 /L were treated at a single center. …Web

Patients selected based on a combination of presenting features and a minimal residual disease (MRD) level <0.01% on day 19 of induction therapy had excellent outcomes with low-intensity treatment. We investigated the impact of MRD levels between 0.001% and <0.01% early in remission induction on the outcome of VLR ALL treated …Web